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Alnylam Pharmaceuticals

RNAi-based drugs for
severe diseases – IPO
Jun 2004 (NASDAQ: ALNY)

AVROBIO

Cell and gene therapies
for rare diseases
IPO Jun 2018 (NASDAQ: AVRO)

Synlogic

Designing Synthetic Biotic
living medicines to treat disease
(NASDAQ: SYBX)

Aerovate Therapeutics

Advancing novel therapies for people
with rare cardiopulmonary disease
– IPO Jun 2021 (NASDAQ: AVTE)

Korro Bio

Leading the
next frontier in
RNA therapeutics

Kymera Therapeutics

Advancing targeted protein
degradation to target previously
“undruggable” disease pathways

Lysosomal Therapeutics, Inc.

Discovering new medicines
for severe
neurodegenerative diseases

Disarm Therapeutics

Preventing axonal degeneration in
patients with neurological diseases
Sold to Lilly (NYSE: LLY) Oct 2020

Cogent Biosciences

Precision therapeutics
for genetically defined
diseases

Kinaset Therapeutics

Novel therapeutics
for severe
respiratory diseases

Scorpion Therapeutics

Broadening the reach and
impact of precision medicine
to more people with cancer

Rodin Therapeutics

Enhancing synaptic integrity for
treatment of neurologic dis-
orders; sold to Alkermes Nov 2019

Novexel

Novel antibiotics –
Sold to AstraZeneca
(NYSE: AZN) Mar 2010

Rectify

Rectify is developing Positive Functional Modulators (PFMs), disease-modifying precision therapeutics that restore ABC transporter function for patients with serious genetic diseases.

ABC transporters are a 48-member family of membrane-bound proteins with etiologic loss-of-function mutations in multiple organ systems and therapeutic areas including the lungs, liver, gastrointestinal tract, eye, and central nervous system.

F-Star Alpha Limited

Bispecific antibodies
to improve the treatment
of serious diseases

Bicycle Therapeutics

Novel bicyclic peptides (bicycles) and
bicycle drug conjugates for cancer
IPO May 2019 (NASDAQ: BCYC)

Stromedix

Novel fibrosis therapeutic –
Sold to Biogen Idec
(NASDAQ: BIIB) Feb 2012

Ikena Oncology

Patient-directed oncology therapies
across immune and cancer cell pathways
IPO Mar 2021 (NASDAQ: IKNA)

Micromet

Cancer therapeutics and
diagnostics – Sold to Amgen
(NASDAQ: AMGN) Jan 2012

Versanis Bio

Developing first-in-class
medicines for medical conditions
prevalent in older adults

U3 Pharma

Human antibody therapies for
oncology – Sold to Daiichi
Sankyo (TYO: 4568) May 2008

Annovation Biopharma

Novel anesthetics –
Sold to The Medicines Company
(NASDAQ: MDCO) Jan 2015

Chroma Medicine

Harnessing the power of the epigenome to develop precision genomic therapeutics.

Triplet Therapeutics

Targeting the DNA damage
response pathway to prevent and
halt expansion repeat disorders

Be Biopharma

Engineered
B cells
as medicines

CoStim Pharmaceuticals

Novel antibodies for immuno-
oncology – Sold to Novartis
(NYSE: NVS) Feb 2014

Obsidian Therapeutics

New class of
regulated cell and
gene therapies

Harbour Antibodies

Mouse platforms for the generation
of fully human antibodies –
Sold to Harbour BioMed Dec 2016

Generation Bio

Scalable, re-dosable, non-viral
gene therapy for genetic diseases
IPO Jun 2020 (NASDAQ: GBIO)

Momenta Pharmaceuticals

Development of complex
biopharma products – IPO
Jun 2004 (NASDAQ: MNTA)

Exelixis

Genomics-based cancer
drug discovery – IPO
Apr 2000 (NASDAQ: EXEL)

Actelion

Therapies for severe
cardiovascular diseases –
IPO Apr 2000 (SWX: ATLN)

ArQule

Novel cancer drugs using
combinatorial chemistry –
IPO Oct 1996 (NASDAQ: ARQL)

Arrow Therapeutics

Anti-viral therapies –
Sold to AstraZeneca
(NYSE: AZN) Feb 2007

Infacare

Proprietary pharmaceuticals for
neonatal care and pediatrics –
Sold to Mallinckrodt Aug 2017

Day One Biopharmaceuticals

Rapidly developing new cancer
treatments for people of all ages
– IPO Jun 2021 (NASDAQ: DAWN)

deCODE genetics

Genetic analysis to find novel
drug targets – Sold to Amgen
(NASDAQ: AMGN) Dec 2012

Replimune

Next-generation oncolytic immuno-
therapies for cancer treatment
– IPO Jul 2018 (NASDAQ: REPL)

Navitor Pharmaceuticals

Novel therapeutics
targeting
diseases of aging

Adnexus Therapeutics

Novel bio-therapies –
Sold to Bristol-Myers Squibb
(NYSE: BMY) Oct 2007

Avila Therapeutics

Covalent irreversible
inhibitors – Sold to Celgene
(NASDAQ: CELG) Jan 2012

Cadent Therapeutics

Breakthrough therapies for neuro-
logical & psychiatric conditions
– Sold to Novartis Dec 2020

Dyne Therapeutics

Pioneering targeted therapies
for serious muscle diseases –
IPO Sep 2020 (NASDAQ: DYN)

Spero Therapeutics

Novel therapies for severe, highly
drug-resistant bacterial infections
IPO Nov 2017 (NASDAQ: SPRO)

Disc Medicine

Applying new insights in
hepcidin biology to
treat hematologic diseases

Intellia Therapeutics

Precision gene editing to
cure severe diseases –
IPO May 2016 (NASDAQ: NTLA)

IFM Therapeutics

Utilizing the innate immune
system to treat cancer and
inflammatory diseases

Magenta Therapeutics

Transforming stem cell transplant
therapy for auto-immune and blood-
based diseases (NASDAQ: MGTA)

Affinia Therapeutics

Building
the future of
gene therapy

HotSpot Therapeutics

Unlocking nature’s regulatory
mechanisms to fuel the
discovery of new medicines

Q32 Bio

Targeting regulators of
innate and adaptive immunity
to restore immune homeostasis

Arteaus Therapeutics

Migraine prevention therapy –
Sold to Eli Lilly (NYSE: LLY)
Dec 2013

Xilio Therapeutics

Harnessing the immune system
to defeat cancer with
tumor-selective immunotherapies

Padlock Therapeutics

Novel medicines for auto-
immune diseases – Sold to
BMS (NYSE:BMY) Mar 2016

Vedere Bio II

Next generation ocular gene
therapies for vision restoration
and vision preservation

Accent Therapeutics

Targeting RNA-modifying
proteins for novel
precision cancer therapies

Vitae Pharmaceuticals

Novel therapeutics using proprietary
computational chemistry –
Sold to Allergan (NYSE: AGN) Sep 2016

Larimar Therapeutics

Developing treatments for
complex rare diseases
(NASDAQ: LRMR)

Akero Therapeutics

Restoring metabolic balance to treat
NASH and serious metabolic diseases
– IPO Jun 2019 (NADSAQ: AKRO)

Vigil Neuroscience

Harnessing the power of microglia
to transform treatments for
neurodegenerative diseases

Remix Therapeutics

Reprogramming RNA processing
to address underlying
drivers of disease

Translate Bio

First-in-class RNA therapies
for severe genetic diseases
IPO Jun 2018 (NASDAQ: TBIO)

Nimbus Therapeutics

Breakthrough computer-aided
drug design
for transformative medicines

Surface Oncology

Novel antibodies built to break
through the tumor microenvironment
IPO Apr 2018 (NASDAQ: SURF)

Gemini Therapeutics

Precision therapeutics for
genetically-defined dry AMD
(NASDAQ: GMTX) Jan 2021

Arkuda Therapeutics

Targeting progranulin and
lysosomal biology to treat
neurodegenerative diseases

Curie Therapeutics

Curie Therapeutics is discovering and developing safe, effective, and highly targeted radiopharmaceuticals.

Crucell

Novel vaccine platform –
Sold to Johnson & Johnson
(NYSE: JNJ) Oct 2010

Delinia

Novel biologic therapeutics for
autoimmune diseases – Sold to
Celgene (NASDAQ: CELG) Jan 2017

MorphoSys

World-class antibody
discovery platform – IPO
Mar 1999 (XETRA: MOR.DE)