|   In the News

Startup Spotlight: Aiming to speed precision cancer therapies to children

For some children with a certain type of brain tumor, treatment can mean surgery followed by multiple rounds of chemotherapy infusions to beat back the growth of their low-grade gliomas. A San Francisco startup hopes to change that trajectory with an oral therapy targeting specific proteins mutated in these cancers, part of a larger game plan to make precision treatments as available for kids with cancer as they are for adults.

Day One Biopharmaceuticals — named for the conversations clinicians have with parents when they first tell them their child has cancer and how they hope to treat it — announced on Thursday its first financing and its first drug candidate.

Read more.


  |   In the News

HotSpot announces $65M Series B, as Nimbus pioneers look to keep up in a crowding field

In the decade since Nimbus Therapeutics built a company around computation and little-known phenomena allosteric regulation, the industry has brimmed with algorithm companies and even a few chasing those same targets. Still, a couple of the old leaders think they can keep an edge. “We’re very proud to have pioneered the field,” Gerry Harriman told Endpoints News. “And we’re also very proud to say our portfolio is full of targets that have allosteric inhibitors really for the first time that has ever been described.”

Read more.


  |   From the Trenches

The Business Of Science

Today marks an important milestone for HotSpot Therapeutics as we announce our Series B financing, but it also marks a milestone for me personally – 20 years in the business of biotech.

This blog was written by Jonathan Montagu, CEO and co-founder of HotSpot Therapeutics, as part of the From The Trenches feature of LifeSciVC.

Read more .


  |   In the News

Biotech CEOs Share Ideas for Coping With Coronavirus

When the pandemic struck, biotechnology chief executives suddenly faced questions about how to keep their workers safe, their research moving and their budgets intact.

Read more.


  |   From the Trenches

Ordinary People Achieving The Extraordinary: Lessons In Leadership From The Court To The C-suite

I stood in front of 15 skeptical parents and prepared to sell them on an improbable mission.

They had all signed their daughters up for the first-grade basketball team. I would be coaching that team. And I was here to advise them that this would not be the type of experience their six- and seven-year-olds were used to.

This blog was written by Josh Brumm, CEO of Dyne Therapeutics, as part of the From The Trenches feature of LifeSciVC.

Read more.